Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634739 | 1.00 | KMT2A (0.55) | KMT2AHCAR3MAPTAKR1C3AKR1C2 | |
| SCHEMBL16634625 | 0.89 | HCAR3 (0.52) | KMT2AHCAR3MAPTAKR1C3AKR1C2 | |
| SCHEMBL16634623 | 0.89 | HCAR3 (0.52) | KMT2AHCAR3MAPTAKR1C3AKR1C2 | |
| SCHEMBL16634584 | 0.85 | CREBBP (0.49) | KMT2AHCAR3MAPTAKR1C3AKR1C2 | |
| SCHEMBL20985428 | 0.80 | HCAR3 (0.49) | KMT2AHCAR3MAPTMEN1LMNA | |
| SCHEMBL20985427 | 0.80 | HCAR3 (0.49) | KMT2AHCAR3MAPTMEN1LMNA | |
| SCHEMBL14852475 | 0.78 | CREBBP (0.41) | KMT2AHCAR3MAPTAKR1C3AKR1C2 | |
| SCHEMBL3811958 | 0.78 | KMT2A (0.64) | KMT2AMEN1CREBBPNPC1ALDH1A1 | |
| SCHEMBL20985435 | 0.76 | ALDH1A1 (0.38) | KMT2AHCAR3MAPTMEN1CREBBP | |
| SCHEMBL3078394 | 0.76 | KMT2A (0.45) | KMT2AHCAR3MAPTMEN1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |