Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | GFER | P55789 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634584 | 0.88 | CREBBP (0.49) | CREBBPMEN1KMT2AEP300GAA | |
| SCHEMBL16634625 | 0.85 | HCAR3 (0.52) | CREBBPMEN1KMT2AEP300MAPT | |
| SCHEMBL16634623 | 0.85 | HCAR3 (0.52) | CREBBPMEN1KMT2AEP300MAPT | |
| SCHEMBL16645316 | 0.81 | CREBBP (0.44) | CREBBPMEN1KMT2AEP300GAA | |
| SCHEMBL3811958 | 0.77 | KMT2A (0.64) | CREBBPMEN1KMT2AEP300ALDH1A1 | |
| SCHEMBL20985266 | 0.77 | ALOX15 (0.41) | CREBBPMEN1KMT2AEP300GAA | |
| SCHEMBL20985264 | 0.77 | ALOX15 (0.41) | CREBBPMEN1KMT2AEP300GAA | |
| SCHEMBL16645348 | 0.75 | CREBBP (0.38) | CREBBPMEN1KMT2AEP300GAA | |
| SCHEMBL4505041 | 0.74 | MEN1 (0.54) | CREBBPMEN1KMT2AEP300GFER | |
| SCHEMBL2881940 | 0.74 | MEN1 (0.44) | CREBBPMEN1KMT2AEP300SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |