Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 6/20 | 0.61 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12201798 | 0.88 | PRMT3 (0.64) | PRMT3IMPDH2NOTUM | |
| Hydrochloric Acid SCHEMBL111600 | 0.87 | PRMT3 (0.62) | PRMT3IMPDH2NOTUM | |
| SCHEMBL21430054 | 0.86 | IMPDH2 (0.62) | PRMT3IMPDH2NOTUM | |
| SCHEMBL30176801 | 0.84 | KDM4E (0.66) | PRMT3IMPDH2NOTUMKDM4EALDH1A1 | |
| SCHEMBL20262924 | 0.84 | KDM4E (0.66) | PRMT3IMPDH2NOTUMKDM4EALDH1A1 | |
| SCHEMBL19860095 | 0.84 | IMPDH2 (0.62) | PRMT3IMPDH2NOTUM | |
| SCHEMBL19860105 | 0.83 | PRMT3 (0.62) | PRMT3IMPDH2NOTUM | |
| SCHEMBL2162755 | 0.82 | NOTUM (0.62) | PRMT3IMPDH2NOTUM | |
| SCHEMBL12201759 | 0.82 | IMPDH2 (0.61) | PRMT3IMPDH2NOTUM | |
| SCHEMBL19860096 | 0.82 | NOTUM (0.65) | PRMT3IMPDH2NOTUMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| EP-3055304-A1 | NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS | Eli Lilly and Company (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054060-A1 | NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS | ELI LILLY AND COMPANY (US) | 2015-04-16 | — | — | WO | disclosed |