Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.65 |
| ▸ | PRMT3 | O60678 | 4/20 | 0.57 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860094 | 0.86 | NOTUM (0.68) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL12201798 | 0.85 | PRMT3 (0.64) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL19860100 | 0.84 | NOTUM (0.65) | NOTUMPRMT3IMPDH2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL111600 | 0.83 | PRMT3 (0.62) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL19860099 | 0.83 | NOTUM (0.64) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL16634909 | 0.82 | PRMT3 (0.61) | NOTUMPRMT3IMPDH2HPGDALDH1A1 | |
| SCHEMBL12202000 | 0.82 | NOTUM (0.76) | NOTUMPRMT3IMPDH2NAMPTNPC1 | |
| SCHEMBL4428374 | 0.82 | NOTUM (0.62) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL3066012 | 0.81 | IMPDH2 (0.63) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL30176801 | 0.81 | KDM4E (0.66) | NOTUMPRMT3IMPDH2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |