Fenbendazole

Fenbendazole

SCHEMBL166352

COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TUB2

The experimentally established mechanism targets of Fenbendazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 8/20 0.82
CYP1A2 P05177 5/20 0.82
MEN1 O00255 2/20 0.82
KMT2A Q03164 2/20 0.82
NR1I2 O75469 1/20 0.82
MAPK14 Q16539 1/20 0.82
KDR P35968 5/20 0.56
HIF1A Q16665 4/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
ALDH1A1 P00352 2/20 0.56
CYP2C19 P33261 1/20 0.56
ABCC4 O15439 1/20 0.56
USP2 O75604 1/20 0.56
ABL1 P00519 1/20 0.56
CYP2C9 P11712 1/20 0.56
HTT P42858 1/20 0.56
HPGD P15428 3/20 0.54
MAPK1 P28482 3/20 0.54
TP53 P04637 1/20 0.54
KCNH2 Q12809 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenbendazole SCHEMBL3988034 1.00 LMNA (0.82) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL31547342 1.00 LMNA (0.82) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL31547327 1.00 LMNA (0.82) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL9639071 0.99 LMNA (0.80) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL28228589 0.99 LMNA (0.80) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL845544 0.96 LMNA (0.81) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL28193035 0.95 LMNA (0.76) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL4981601 0.91 LMNA (0.70) LMNACYP1A2MEN1KMT2ANR1I2
SCHEMBL24359625 0.90 LMNA (0.67) LMNACYP1A2MEN1KMT2ANR1I2
Fenbendazole SCHEMBL8469702 0.90 LMNA (1.00) LMNACYP1A2MEN1KMT2ANR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7781 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122039076-A Preparation method of 2-methyl sulfoxide pyrimidine derivative 石河子大学 2026-05-15 CN claimed
US-20260097100-A1 CANCER TREATMENT BY INDUCTION OF TUMOR AND STEM CELL DIFFERENTIATION LATHAM KEITH ROGER (US) 2026-04-09 US claimed
WO-2026044269-A1 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING ALZHEIMER'S DISEASE AND OTHER SAFWAT SHERIF (US) 2026-02-26 WO claimed
EP-4687480-A2 MATERIALS AND METHODS FOR THE MANUFACTURE OF AN ANIMAL FEED In the Bowl Animal Health, Inc. (US) 2026-02-11 EP claimed
US-20260026529-A1 MATERIALS AND METHODS FOR THE MANUFACTURE OF AN ANIMAL FEED IN THE BOWL ANIMAL HEALTH INC (US) 2026-01-29 US claimed
EP-4680240-A1 METHOD OF TREATING DISORDERS WITH SURF1 MALFUNCTION Cure Mito Foundation (US) 2026-01-21 EP claimed
US-12496374-B2 Deodorizer composition, absorbing body, and absorbent article SUMITOMO SEIKA CHEMICALS CO, LTD. (JP) 2025-12-16 US claimed
US-20250352518-A1 A BENZIMIDAZOLE COMPOUND WITH ANTIHELMINTHIC ACTIVITY FOR USE IN REVERSING, ARRESTING OR SLOWING DOWN CELLULAR AGEING IN A VERTEBRATE SUBJECT RAVAN BIO LIMITED (GB) 2025-11-20 US claimed
US-12465623-B2 Use of parasites and extracellular vesicles obtained from parasites in cancer treatment YEDITEPE UNIVERSITESI (TR) 2025-11-11 US claimed
US-20250333775-A1 DIAGNOSTIC TEST AND THERAPY FOR PATIENTS WITH AUTO-BREWERY SYNDROME UNIV CALIFORNIA (US) 2025-10-30 US claimed
EP-0146573-A1 PHARMACEUTICAL COMPOSITIONS WITH ANTHELMINTIC ACTIVITY, DOSAGE UNITS THEREOF AND METHOD FOR TREATING HELMINTHIASIS IN ANIMALS HOECHST AKTIENGESELLSCHAFT (DE) 1985-07-03 EP claimed
WO-1984004677-A1 PHARMACEUTICAL COMPOSITIONS WITH ANTHELMINTIC ACTIVITY, DOSAGE UNITS THEREOF AND METHOD FOR TREATING HELMINTHIASIS IN ANIMALS HOECHST AG (DE) 1984-12-06 WO claimed
WO-1984004455-A1 POTENTIATION OF ANTHELMINTICS COMMW SCIENT IND RES ORG (AU) 1984-11-22 WO claimed
EP-0060810-B1 ANTHELMINTICS CIBA-GEIGY AG (CH) 1984-10-17 EP claimed
EP-0059074-B1 ANTHELMINTIC COMPOSITION AND THE USE THEREOF SANKYO COMPANY LIMITED (JP) 1984-10-10 EP claimed
US-4468390-A Anthelmintic composition and the use thereof SANKYO COMPANY, LIMITED (JP) 1984-08-28 US claimed
EP-0025696-B1 CONTROLLED RELEASE PARASITICIDAL FORMULATIONS ELI LILLY AND COMPANY (US) 1984-04-04 EP claimed
EP-0090368-A1 Anthelmintic preparations HOECHST UK LIMITED (GB) 1983-10-05 EP claimed
EP-0059074-A1 Anthelmintic composition and the use thereof SANKYO COMPANY LIMITED (JP) 1982-09-01 EP claimed
EP-0025696-A2 Controlled release parasiticidal formulations ELI LILLY AND COMPANY (US) 1981-03-25 EP claimed