Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenbendazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenbendazole SCHEMBL30384658 | 1.00 | LMNA (1.00) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL31076495 | 0.92 | LMNA (0.85) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| SCHEMBL31197291 | 0.90 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| SCHEMBL31197292 | 0.90 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL31547342 | 0.90 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL3988034 | 0.90 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL166352 | 0.90 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL31547327 | 0.90 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL845544 | 0.90 | LMNA (0.81) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL28228589 | 0.89 | LMNA (0.80) | LMNACYP1A2MEN1KMT2ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 716 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260097888-A1 | SAFE GUARD ZIPPER BAG | STANDPACK CO., LTD. (KR) | 2026-04-09 | — | — | US | claimed |
| US-12500049-B2 | Emulated voltage-free safety contact | TELEVIC RAIL NV (BE) | 2025-12-16 | — | — | US | claimed |
| US-12431813-B2 | Power converting system | DELTA ELECTRONICS (SHANGHAI) CO., LTD. (CN) | 2025-09-30 | — | — | US | claimed |
| WO-2025151711-A1 | NUCLEIC ACID VACCINES TARGETING METHANOGENS | Arkea Bio Corp. (US) | 2025-07-17 | — | — | WO | claimed |
| WO-2025151713-A1 | PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS | Arkea Bio Corp. (US) | 2025-07-17 | — | — | WO | claimed |
| US-20250222082-A1 | PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS | ARKEA BIO CORP (US) | 2025-07-10 | — | — | US | claimed |
| CN-120197889-A | Intelligent flood discharge scheduling method for small reservoir based on reinforcement learning | 常州工学院 | 2025-06-24 | — | — | CN | claimed |
| WO-2025128700-A1 | CELL-BASED VACCINES | Arkea Bio Corp. (US) | 2025-06-19 | — | — | WO | claimed |
| CN-120047707-A | Method, system, equipment and medium for on-line detection of unsafe behavior by AI | 中国石油化工股份有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-222869624-U | Security protection fence for livestock breeding industry | 湖北九邦现代农业有限公司 | 2025-05-16 | — | — | CN | claimed |
| WO-2022125126-A1 | EMERGENCY FIRE ESCAPE DEVICES OF THE OFF SHORE RIGS WITH EMPHASIS ON A DETACHABLE ISLAND RIG | PATURU SUMATHI (US) | 2022-06-16 | — | — | WO | claimed |
| US-11356329-B2 | Network intent synthesis | AT&T INTELLECTUAL PROPERTY I, L.P. (US) | 2022-06-07 | — | — | US | claimed |
| CN-114501889-A | Data processing system for computer software development | 中玥信息技术(深圳)有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-216248794-U | Intelligent household equipment of mutual accuse of multiple spot pronunciation | 黑龙江顽狐科技开发有限公司 | 2022-04-08 | — | — | CN | claimed |
| WO-2022071980-A1 | SYSTEM AND METHOD FOR PREDICTING SHUTDOWN ALARMS IN BOILER USING MACHINE LEARNING | CLEAVER-BROOKS, INC. (US) | 2022-04-07 | — | — | WO | claimed |
| CN-215944823-U | Multifunctional fishing inflatable boat | 荣成百邦电子有限公司 | 2022-03-04 | — | — | CN | claimed |
| CN-215795249-U | Sample storage protection box for computer science and technology teaching | 焦原驰 | 2022-02-11 | — | — | CN | claimed |
| EP-0059074-B1 | ANTHELMINTIC COMPOSITION AND THE USE THEREOF | SANKYO COMPANY LIMITED (JP) | 1984-10-10 | — | — | EP | claimed |
| US-4468390-A | Anthelmintic composition and the use thereof | SANKYO COMPANY, LIMITED (JP) | 1984-08-28 | — | — | US | claimed |
| EP-0059074-A1 | Anthelmintic composition and the use thereof | SANKYO COMPANY LIMITED (JP) | 1982-09-01 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260097888-A1 | SAFE GUARD ZIPPER BAG | HSPBP1, LNPK, BAG2 | LMNA 973/4885CYP1A2 4657/4885MEN1 1545/4885 |
| US-20250222082-A1 | PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS | MCRS1, VIP, HM13 | LMNA 4701/4885CYP1A2 3576/4885MEN1 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.