Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenbendazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.82 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.82 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenbendazole SCHEMBL166352 | 1.00 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL31547342 | 1.00 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL31547327 | 1.00 | LMNA (0.82) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL9639071 | 0.99 | LMNA (0.80) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL28228589 | 0.99 | LMNA (0.80) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL845544 | 0.96 | LMNA (0.81) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL28193035 | 0.95 | LMNA (0.76) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL4981601 | 0.91 | LMNA (0.70) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| SCHEMBL24359625 | 0.90 | LMNA (0.67) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL8469702 | 0.90 | LMNA (1.00) | LMNACYP1A2MEN1KMT2ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009065141-A1 | METHODS AND COMPOSITIONS FOR REDUCING SKIN DAMAGE | THE GENERAL HOSPITAL CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |