Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215127 | 0.81 | MAPT (0.36) | LMNAADORA3 | |
| SCHEMBL16636480 | 0.72 | KDM4E (0.50) | GAAADORA3 | |
| SCHEMBL16636639 | 0.65 | ADORA3 (0.36) | ADORA3 | |
| SCHEMBL30326993 | 0.61 | KDM4E (0.50) | LMNAGAAADORA3 | |
| SCHEMBL24417113 | 0.59 | SMN1; SMN2 (0.47) | LMNAALOX15TDP1ADORA3 | |
| SCHEMBL3536702 | 0.59 | KMT2A (0.56) | LMNAGAATDP1 | |
| SCHEMBL2891361 | 0.59 | LMNA (0.37) | LMNA | |
| SCHEMBL1021249 | 0.59 | CHEK1 (0.46) | LMNATDP1ADORA3 | |
| SCHEMBL3490995 | 0.58 | ADORA3 (0.39) | ADORA3 | |
| SCHEMBL28693407 | 0.57 | ADORA3 (0.42) | TDP1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |