Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636480 | 0.73 | KDM4E (0.50) | ADORA3DHODH | |
| SCHEMBL9215127 | 0.72 | MAPT (0.36) | ADORA3DHODH | |
| SCHEMBL21193526 | 0.68 | EIF2AK4 (0.34) | — | |
| SCHEMBL30804028 | 0.67 | MCHR1 (0.32) | — | |
| SCHEMBL21193589 | 0.66 | EIF2AK4 (0.34) | — | |
| SCHEMBL23415591 | 0.66 | ALPI (0.38) | — | |
| SCHEMBL16636610 | 0.65 | LMNA (0.33) | ADORA3 | |
| SCHEMBL30658187 | 0.64 | ITGA2B (0.30) | — | |
| SCHEMBL30658182 | 0.64 | GABRA1 (0.37) | ADORA3 | |
| SCHEMBL30658191 | 0.64 | ITGA2B (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988400-B2 | Thiazolopyrimidinones and methods of use thereof | GENENTECH, INC. (US) | 2018-06-05 | — | — | US | claimed |
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |