Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593446 | 0.83 | TSHR (0.44) | KDM4EIDO1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL29945861 | 0.82 | KDM4E (0.33) | KDM4EIDO1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL16637855 | 0.82 | NOTUM (0.43) | KDM4EIDO1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL23526137 | 0.82 | KDM4E (0.33) | KDM4EIDO1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL16638001 | 0.78 | NPC1 (0.48) | ALDH1A1LMNAL3MBTL1NPC1MEN1 | |
| SCHEMBL23326804 | 0.78 | KIF11 (0.38) | KDM4EALDH1A1HSD17B10GAATSHR | |
| SCHEMBL16647668 | 0.77 | KDM4E (0.47) | KDM4EIDO1ALDH1A1HSD17B10GAA | |
| SCHEMBL16529867 | 0.76 | KDM4E (0.44) | KDM4EIDO1ALDH1A1HSD17B10GAA | |
| SCHEMBL24566862 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1HSD17B10GAACYP3A4 | |
| SCHEMBL24566864 | 0.75 | HDAC4 (0.34) | ALDH1A1GAALMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051496-A1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |