SCHEMBL7593446

SCHEMBL7593446

CCOC(=O)c1cc(C(F)(F)F)c(F)c(F)c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
NPSR1 Q6W5P4 2/20 0.43
TP53 P04637 1/20 0.43
HTT P42858 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
MRGPRX4 Q96LA9 1/20 0.41
STAT3 P40763 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7591337 0.88 ALDH1A1 (0.47) TSHRKDM4EALDH1A1L3MBTL1TP53
SCHEMBL7590153 0.85 TSHR (0.50) TSHRALDH1A1L3MBTL1TP53TDP1
SCHEMBL7595389 0.84 TSHR (0.51) TSHRKDM4EALDH1A1L3MBTL1TP53
SCHEMBL16637855 0.83 NOTUM (0.43) TSHRKDM4EALDH1A1L3MBTL1HDAC3
SCHEMBL16637355 0.83 KDM4E (0.47) TSHRKDM4EALDH1A1L3MBTL1HDAC3
SCHEMBL7595676 0.83 ALDH1A1 (0.49) TSHRKDM4EALDH1A1NPSR1TP53
SCHEMBL7595297 0.81 CFTR (0.50) KDM4ECA12CA1CA2CA7
SCHEMBL2001481 0.81 TSHR (0.52) TSHRKDM4EALDH1A1L3MBTL1NPSR1
SCHEMBL7592823 0.81 ALDH1A1 (0.42) TSHRKDM4EALDH1A1L3MBTL1HTT
SCHEMBL7595049 0.80 CTSS (0.33) KDM4EALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0968994-B1 PROCESS FOR PRODUCING SUBSTITUTED TRIFLUOROBENZOIC ACIDS AND ESTERS THEREOF UBE INDUSTRIES (JP) 2002-11-06 EP claimed
EP-0968994-A1 SUBSTITUTED TRIFLUOROBENZOIC ACIDS, ESTERS THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES, LTD. (JP) 2000-01-05 EP claimed
JP-11080075-A None JP disclosed
EP-0968994-B1 PROCESS FOR PRODUCING SUBSTITUTED TRIFLUOROBENZOIC ACIDS AND ESTERS THEREOF UBE INDUSTRIES (JP) 2002-11-06 EP disclosed
US-6307091-B1 TRIFLUOROMETHYLATING A TRIFLUOROIODOBENZOIC ACID ESTER WITH ADIFLUORO(FLUOROSULFONYL)ACETIC ACID ESTER IN THE PRESENCE OF A COPPER CATALYST IN AN ORGANIC SOLVENT. UBE INDUSTRIES, LTD. (JP) 2001-10-23 US disclosed
US-6160171-A Trifluoro-substituted benzoic acid, esters thereof, and process for producing the same UBE INDUSTRIES, LTD. (JP) 2000-12-12 US disclosed
EP-0968994-A1 SUBSTITUTED TRIFLUOROBENZOIC ACIDS, ESTERS THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES, LTD. (JP) 2000-01-05 EP disclosed
JP-H1180075-A 2,3,4-TRIFLUORO-5-TRIFLUOROMETHYLBENZOIC ACID, ITS ESTERS AND THEIR PRODUCTION UBE IND LTD 1999-03-23 JP disclosed