Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593446 | 0.83 | TSHR (0.44) | KDM4EALDH1A1L3MBTL1TSHRMAPT | |
| SCHEMBL31349595 | 0.83 | NOTUM (0.54) | NOTUMALDH1A1L3MBTL1MAPTMRGPRX4 | |
| SCHEMBL16637355 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1L3MBTL1TSHRMAPT | |
| SCHEMBL16638001 | 0.78 | NPC1 (0.48) | ALDH1A1L3MBTL1MAPTLMNASMN1; SMN2 | |
| SCHEMBL15898866 | 0.77 | LMNA (0.41) | NOTUMKDM4EALDH1A1TSHRMAPT | |
| SCHEMBL16647670 | 0.77 | PTPN2 (0.43) | NOTUMKDM4EALDH1A1L3MBTL1TSHR | |
| SCHEMBL25111974 | 0.76 | EPRS1 (0.46) | NOTUMKDM4EALDH1A1 | |
| SCHEMBL30483541 | 0.76 | EPRS1 (0.46) | NOTUMKDM4EALDH1A1 | |
| SCHEMBL671602 | 0.74 | NOTUM (0.71) | NOTUMMAPTLMNACA12CA1 | |
| SCHEMBL22207738 | 0.74 | JMJD6 (0.45) | KDM4EALDH1A1L3MBTL1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051496-A1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |