SCHEMBL16637376

SCHEMBL16637376

O=C(O)N1CCN(c2ncc3cccc(-c4ccccc4Cl)c3n2)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
HCRTR1 O43613 1/20 0.43
HCRTR2 O43614 1/20 0.43
HCAR2 Q8TDS4 1/20 0.42
KDM4E B2RXH2 5/20 0.41
PTPN11 Q06124 3/20 0.41
CNR2 P34972 1/20 0.41
SMO Q99835 3/20 0.40
ALDH1A1 P00352 5/20 0.40
MAPT P10636 3/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
HTT P42858 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
HPGD P15428 1/20 0.40
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39
SLC6A7 Q99884 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16636975 0.88 ALDH1A1 (0.45) MEN1KMT2AHCRTR1HCRTR2KDM4E
SCHEMBL29765700 0.88 ALDH1A1 (0.45) MEN1KMT2AHCRTR1HCRTR2KDM4E
SCHEMBL29766047 0.84 CNR1 (0.52) PTPN11CNR2SMOMAPTPOLB
SCHEMBL16647151 0.84 CNR1 (0.52) PTPN11CNR2SMOMAPTPOLB
SCHEMBL16647188 0.81 HTR7 (0.48) MEN1KMT2AKDM4EPTPN11CNR2
SCHEMBL17026581 0.80 PDE10A (0.37) MEN1KMT2AHCRTR1HCRTR2PTPN11
SCHEMBL16637203 0.79 ABL1 (0.44) MEN1KMT2AHCRTR1HCRTR2HCAR2
SCHEMBL2893092 0.72 S1PR1 (0.50) MEN1KMT2AKDM4ECNR2SMO
SCHEMBL4125912 0.71 ALDH1A1 (0.52) KMT2APTPN11CNR2ALDH1A1MAPT
SCHEMBL3931925 0.68 CNR2 (0.51) CNR2SMOALDH1A1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20210188869-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2021-06-24 US disclosed
US-10927125-B2 Substituted cinnolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2021-02-23 US disclosed
EP-3193851-B1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2020-10-21 EP disclosed
EP-3636639-A1 INHIBITORS OF KRAS G12C Araxes Pharma LLC (US) 2020-04-15 EP disclosed
US-20200102321-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2020-04-02 US disclosed
EP-3055290-B1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2019-10-02 EP disclosed
US-10370386-B2 Substituted quinolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2019-08-06 US disclosed
US-10111874-B2 Combination therapies for treatment of cancer ARAXES PHARMA LLC (US) 2018-10-30 US disclosed
US-20180118757-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2018-05-03 US disclosed
US-9840516-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2017-12-12 US disclosed
EP-3193851-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER Araxes Pharma LLC (US) 2017-07-26 EP disclosed
EP-3055290-A1 INHIBITORS OF KRAS G12C Araxes Pharma LLC (US) 2016-08-17 EP disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210188869-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MEN1 138/4885KMT2A 850/4885HCRTR1 4661/4885
US-10927125-B2 Substituted cinnolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS MEN1 38/4885KMT2A 1804/4885HCRTR1 4256/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS MEN1 188/4885KMT2A 736/4885HCRTR1 4821/4885
US-20200102321-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MEN1 188/4885KMT2A 736/4885HCRTR1 4821/4885
US-10111874-B2 Combination therapies for treatment of cancer KRAS, TP53, HRAS MEN1 872/4885KMT2A 1502/4885HCRTR1 4658/4885
US-20180118757-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MEN1 188/4885KMT2A 736/4885HCRTR1 4821/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MEN1 138/4885KMT2A 850/4885HCRTR1 4661/4885
US-10370386-B2 Substituted quinolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS MEN1 159/4885KMT2A 479/4885HCRTR1 4669/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MEN1 138/4885KMT2A 850/4885HCRTR1 4661/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MEN1 138/4885KMT2A 850/4885HCRTR1 4661/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MEN1 138/4885KMT2A 850/4885HCRTR1 4661/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS MEN1 872/4885KMT2A 1502/4885HCRTR1 4658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.