SCHEMBL16637446

SCHEMBL16637446

NC(=O)C1CN(c2nccc3cc(Cl)ccc23)CCN1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EIF2AK4 Q9P2K8 1/20 0.41
ADRB2 P07550 1/20 0.40
NCF1 P14598 1/20 0.40
FPR2 P25090 1/20 0.39
SCN9A Q15858 1/20 0.39
HTR2C P28335 1/20 0.38
ALDH1A1 P00352 1/20 0.38
PRKD1 Q15139 1/20 0.38
MAT2A P31153 1/20 0.38
HTR1A P08908 1/20 0.37
HTR1D P28221 1/20 0.37
HTR1B P28222 1/20 0.37
CLK1 P49759 1/20 0.37
CCR5 P51681 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
DPP4 P27487 1/20 0.36
KIT P10721 1/20 0.36
IDE P14735 1/20 0.36
PDE10A Q9Y233 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16637571 0.82 PRKD1 (0.38) ADRB2NCF1HTR2CALDH1A1PRKD1
SCHEMBL3683092 0.76 HTR2C (0.64) ADRB2NCF1HTR2CPRKD1HTR1A
Hydrochloric Acid SCHEMBL31587078 0.75 HTR2C (0.62) ADRB2NCF1HTR2CPRKD1HTR1A
SCHEMBL16636885 0.74 KRAS (0.39) ALDH1A1HTR1AHTR1DHTR1BCLK1
SCHEMBL16647244 0.73 PDE10A (0.46) FPR2SCN9AKITPDE10A
SCHEMBL16636831 0.73 PDE10A (0.46) FPR2SCN9AKITPDE10A
SCHEMBL30471791 0.73 HTR1A (0.54) FPR2SCN9AHTR2CALDH1A1HTR1A
SCHEMBL4023615 0.71 MAT2A (0.47) HTR2CMAT2AMEN1KMT2AKIT
SCHEMBL17844907 0.70 HTR2C (0.53) HTR2CPRKD1DPP4
SCHEMBL4023613 0.70 MAT2A (0.41) ALDH1A1MAT2AHTR1AHTR1DHTR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20220242875-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2022-08-04 US disclosed
US-20210188869-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2021-06-24 US disclosed
EP-3193851-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER Araxes Pharma LLC (US) 2017-07-26 EP disclosed
EP-3055290-A1 INHIBITORS OF KRAS G12C Araxes Pharma LLC (US) 2016-08-17 EP disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210188869-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885ADRB2 2352/4885NCF1 2471/4885
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2589/4885ADRB2 3257/4885NCF1 2865/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2112/4885ADRB2 1760/4885NCF1 2538/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2112/4885ADRB2 1760/4885NCF1 2538/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885ADRB2 2352/4885NCF1 2471/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885ADRB2 2352/4885NCF1 2471/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885ADRB2 2352/4885NCF1 2471/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885ADRB2 2352/4885NCF1 2471/4885
US-20220242875-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885ADRB2 2352/4885NCF1 2471/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS EIF2AK4 1068/4885ADRB2 4602/4885NCF1 947/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.