Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8356328 | 0.75 | CYP1A2 (0.52) | CYP1A2RAB9AKDM4EMAPTPOLB | |
| SCHEMBL16637650 | 0.72 | USP18 (0.46) | RAB9AMAPTTDP1KMT2AMEN1 | |
| SCHEMBL17684483 | 0.71 | CYP1A2 (0.53) | CYP1A2RAB9AKDM4EMAPTPOLB | |
| SCHEMBL31003382 | 0.70 | MAOA (0.41) | RAB9AMAPTPOLBTDP1KMT2A | |
| SCHEMBL31611710 | 0.70 | AKR1C3 (0.46) | KDM4EMAPTPIM1PIM2CYP2A6 | |
| SCHEMBL31378307 | 0.70 | CYP2A6 (0.41) | KDM4ETDP1CYP2A6SMN1; SMN2ALDH1A1 | |
| SCHEMBL31003275 | 0.67 | LMNA (0.40) | RAB9AKDM4EMAPTL3MBTL1KMT2A | |
| SCHEMBL19228790 | 0.67 | CYP1A2 (0.53) | CYP1A2RAB9AKDM4EMAPTPOLB | |
| SCHEMBL31596795 | 0.67 | GUSB (0.41) | CYP1A2RAB9AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL19228792 | 0.65 | CYP1A2 (0.43) | CYP1A2RAB9AKDM4EMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160250303-A1 | PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION | UNIV MIAMI (US) | 2016-09-01 | — | — | US | claimed |
| EP-3054946-A2 | PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION | University Of Miami (US) | 2016-08-17 | — | — | EP | claimed |
| WO-2015054374-A2 | PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION | UNIVERSITY OF MIAMI (US) | 2015-04-16 | — | — | WO | claimed |
| US-20160250303-A1 | PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION | UNIV MIAMI (US) | 2016-09-01 | — | — | US | disclosed |
| EP-3054946-A2 | PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION | University Of Miami (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054374-A2 | PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION | UNIVERSITY OF MIAMI (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160250303-A1 | PERFORIN-2 ACTIVATORS AND INHIBITORS AS DRUG TARGETS FOR INFECTIOUS DISEASE AND GUT INFLAMMATION | PRF1, GZMB, PSME2 | CYP1A2 1640/4885RAB9A 2013/4885KDM4E 3007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.