Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13407783 | 0.79 | NR3C1 (0.41) | NR3C1CYP11B2CYP11B1SRCCHEK1 | |
| SCHEMBL23170668 | 0.75 | CYP11B2 (0.52) | NR3C1CYP11B2CYP11B1 | |
| SCHEMBL10050859 | 0.73 | RECQL (0.43) | CYP11B2CYP11B1 | |
| SCHEMBL17616559 | 0.72 | SMN1; SMN2 (0.33) | CYP11B2CYP11B1SRC | |
| SCHEMBL12775602 | 0.70 | CYP17A1 (0.41) | — | |
| SCHEMBL22593921 | 0.68 | RIPK2 (0.41) | — | |
| SCHEMBL12775610 | 0.67 | CYP17A1 (0.41) | CYP11B2CYP11B1 | |
| SCHEMBL24037212 | 0.67 | ALDH1A1 (0.51) | — | |
| SCHEMBL20021709 | 0.66 | GAA (0.36) | CYP11B2CYP11B1TRPA1 | |
| SCHEMBL14012593 | 0.59 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055301-A1 | RHO KINASE INHIBITORS | Kadmon Corporation, LLC (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054317-A1 | RHO KINASE INHIBITORS | KADMON CORPORATION, LLC (US) | 2015-04-16 | — | — | WO | disclosed |