Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23554173 | 0.81 | GSTO1 (0.55) | LMNAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL23554220 | 0.77 | MEN1 (0.53) | LMNAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL23554175 | 0.77 | GSTO1 (0.49) | LMNAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL504005 | 0.74 | L3MBTL1 (0.55) | MEN1KMT2AALDH1A1GSK3BNPC1 | |
| SCHEMBL14075912 | 0.71 | NPC1 (0.36) | KDM4EMEN1KMT2AMAPTPAX8 | |
| SCHEMBL4600961 | 0.70 | NPC1 (0.36) | KDM4EMEN1KMT2AMAPTPAX8 | |
| SCHEMBL29235800 | 0.70 | GSTO1 (0.40) | HPGDSMAOAACHEMEN1KMT2A | |
| SCHEMBL30073325 | 0.69 | F2 (0.47) | KDM4EMEN1KMT2APAX8GSK3B | |
| SCHEMBL19512762 | 0.69 | L3MBTL1 (0.42) | LMNAKDM4EMEN1KMT2APAX8 | |
| SCHEMBL2880226 | 0.69 | NPC1 (0.53) | LMNAKDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |