Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7195015 | 0.89 | GPR84 (0.60) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL8971829 | 0.88 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL28946733 | 0.85 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL1609629 | 0.82 | TSHR (0.53) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL3453144 | 0.82 | TSHR (0.53) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL18584142 | 0.82 | GPR84 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL2312811 | 0.82 | GPR84 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7190397 | 0.81 | GPR84 (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL598903 | 0.81 | TSHR (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL29566807 | 0.79 | TSHR (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055313-A1 | CYCLIC THIENOURACIL-CARBOXAMIDES AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052065-A1 | CYCLIC THIENOURACIL-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-04-16 | — | — | WO | disclosed |