Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28694203 | 0.93 | RAB9A (0.46) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL7195015 | 0.89 | GPR84 (0.60) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL3453711 | 0.86 | SRD5A1 (0.45) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL29780668 | 0.85 | TSHR (0.59) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL7974044 | 0.85 | TSHR (0.59) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL18584142 | 0.82 | GPR84 (0.55) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL16638077 | 0.82 | SMN1; SMN2 (0.59) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL1609629 | 0.82 | TSHR (0.53) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL2312811 | 0.82 | GPR84 (0.55) | TSHRALDH1A1ATMNPSR1RAB9A | |
| SCHEMBL28519967 | 0.81 | ALDH1A1 (0.42) | TSHRALDH1A1ATMNPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109293641-A | A kind of fluorenes class STAT3 inhibitor and preparation method thereof | 南京先进生物材料与过程装备研究院有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-109223758-A | A kind of taxol and fluorenes class STAT3 inhibitor drug combination compositions | 南京先进生物材料与过程装备研究院有限公司 | 2019-01-18 | — | — | CN | claimed |
| CN-104231023-B | Tricyclic fused heterocycle nucleoside phosphoramidate compound, preparation method and application | 南京汇诚制药有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-109293641-A | A kind of fluorenes class STAT3 inhibitor and preparation method thereof | 南京先进生物材料与过程装备研究院有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-109223758-A | A kind of taxol and fluorenes class STAT3 inhibitor drug combination compositions | 南京先进生物材料与过程装备研究院有限公司 | 2019-01-18 | — | — | CN | disclosed |
| US-7858824-B2 | Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2010-12-28 | — | — | US | disclosed |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | US | disclosed |
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| EP-1438291-B1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-09-07 | — | — | EP | disclosed |
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-01-20 | — | — | US | disclosed |
| EP-1438291-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003033466-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | CYCS, NADK, CYP2F1 | TSHR 3271/4885ALDH1A1 2370/4885ATM 3570/4885 |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | CYP3A43, CYCS, CCNY | TSHR 2962/4885ALDH1A1 2661/4885ATM 4430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.