Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.60 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17088117 | 0.90 | GABRG2 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL18096770 | 0.86 | GABRA3 (0.62) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL19368385 | 0.83 | GABRG2 (0.59) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL16638527 | 0.83 | GABRG2 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL16638528 | 0.83 | GABRG2 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL16638524 | 0.83 | GABRG2 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL13693911 | 0.82 | GABRG2 (0.46) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL16638526 | 0.81 | GABRG2 (0.56) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL13061774 | 0.81 | GABRA1 (0.54) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL13966574 | 0.80 | GABRG2 (0.55) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006233-B2 | Gabaergic receptor subtype selective ligands and their uses | UWM RESEARCH FOUNDATION, INC. (US) | 2015-04-14 | — | — | US | disclosed |