SCHEMBL1663857

SCHEMBL1663857

CCOc1cc(O)c2c(=O)c(OCC)c(-c3ccccc3)oc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 6/20 1.00
ACE2 Q9BYF1 2/20 0.74
EGFR P00533 1/20 0.65
RET P07949 1/20 0.65
KDR P35968 1/20 0.65
POLH Q9Y253 2/20 0.65
ABCB1 P08183 2/20 0.63
PPARG P37231 2/20 0.55
CREB1 P16220 1/20 0.55
CYP3A4 P08684 2/20 0.53
CYP2D6 P10635 2/20 0.53
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
CA12 O43570 1/20 0.53
CYP1A1 P04798 1/20 0.53
CYP1A2 P05177 1/20 0.53
BCHE P06276 1/20 0.53
P4HB P07237 1/20 0.53
MAPT P10636 1/20 0.53
CYP19A1 P11511 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30741225 0.87 ADORA3 (1.00) ADORA3ACE2EGFRRETKDR
SCHEMBL1663784 0.87 ADORA3 (1.00) ADORA3ACE2EGFRRETKDR
SCHEMBL31031138 0.86 ADORA3 (0.75) ADORA3ACE2POLHABCB1PPARG
SCHEMBL18130384 0.81 ABCB1 (0.83) ADORA3POLHABCB1CYP3A4CYP2D6
SCHEMBL117535 0.81 ADORA3 (0.69) ADORA3ACE2POLHABCB1PPARG
Morin Pentaethyl Ether SCHEMBL1664234 0.81 ADORA3 (1.00) ADORA3ACE2EGFRRETKDR
SCHEMBL13081662 0.79 ACE2 (0.72) ADORA3ACE2POLHCYP3A4CYP2D6
SCHEMBL11097722 0.79 ABCG2 (0.82) ADORA3ACE2POLHABCB1PPARG
SCHEMBL7202826 0.79 POLH (1.00) ADORA3ACE2EGFRRETKDR
SCHEMBL17620271 0.79 ACE2 (0.83) ADORA3ACE2POLHABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885192-B8 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) 2012-05-16 EP claimed
EP-0885192-A1 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1998-12-23 EP claimed
WO-1997027177-A2 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN-4-ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-07-31 WO claimed
US-11857600-B2 GPCR heteromer inhibitors and uses thereof GPCR THERAPEUTICS, INC. (KR) 2024-01-02 US disclosed
EP-2311806-A2 Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists The United States of America, Represented by the Secretary, Department of Health and Human Services (US) 2011-04-20 EP disclosed
US-6066642-A FOR SELECTIVELY BLOCKING THE A3 ADENOSINE RECEPTOR OF A MAMMAL THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-05-23 US disclosed