Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773480 | 0.90 | ALDH1A1 (0.54) | ALDH1A1ATMMAPTGSK3BSMN1; SMN2 | |
| SCHEMBL6129016 | 0.81 | NPC1 (0.47) | ALDH1A1MAPTPIK3C3MAPK14SMN1; SMN2 | |
| SCHEMBL13305064 | 0.75 | RAB9A (0.67) | ALDH1A1MAPTPIK3C3SMN1; SMN2RAB9A | |
| SCHEMBL1663874 | 0.74 | WEE1 (0.46) | ALDH1A1JAK2JAK3MAPTSMN1; SMN2 | |
| SCHEMBL13973218 | 0.74 | ALDH1A1 (0.72) | ALDH1A1ATMMAPTEPHX2SMN1; SMN2 | |
| SCHEMBL2339163 | 0.73 | FGFR1 (0.67) | ALDH1A1RAB9A | |
| SCHEMBL1664810 | 0.72 | TNIK (0.43) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8772494 | 0.72 | ALDH1A1 (0.69) | ALDH1A1ATMMAPTSMN1; SMN2RAB9A | |
| SCHEMBL2092723 | 0.72 | TP53 (0.61) | ALDH1A1MAPTGSK3BSMN1; SMN2RAB9A | |
| SCHEMBL2339303 | 0.72 | FGFR1 (0.69) | ALDH1A1MAPTGSK3BRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |