Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664480 | 0.78 | SYK (0.44) | WEE1SMN1; SMN2FGFR1LMNASYK | |
| SCHEMBL1664810 | 0.78 | TNIK (0.43) | WEE1RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8771368 | 0.76 | MAPT (0.54) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL6129016 | 0.75 | NPC1 (0.47) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL1663867 | 0.74 | ALDH1A1 (0.56) | RAB9ASMN1; SMN2NPC1JAK2JAK3 | |
| SCHEMBL1664812 | 0.72 | ESR1 (0.46) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL24865211 | 0.71 | ALDH1A1 (0.46) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL30336404 | 0.71 | ALDH1A1 (0.46) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL444546 | 0.71 | L3MBTL3 (0.41) | LMNAMAPTHTT | |
| SCHEMBL28805590 | 0.70 | NPC1 (0.42) | WEE1RAB9ASMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |