Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SQOR | Q9Y6N5 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28635180 | 0.80 | KMT2A (0.50) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL13144468 | 0.80 | SQOR (0.57) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL13422264 | 0.76 | DHODH (0.53) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL24457916 | 0.75 | CCR1 (0.37) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL29956027 | 0.75 | KMT2A (0.46) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL12960812 | 0.75 | KMT2A (0.46) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL29223019 | 0.73 | MAPT (0.45) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL4056518 | 0.73 | DHODH (0.54) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL13752829 | 0.72 | GABRA1 (0.50) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL29206981 | 0.72 | KMT2A (0.44) | KMT2AMAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | disclosed |