SCHEMBL16640321

SCHEMBL16640321

CC(C)c1ccc(-n2c3ccccc3c3ccncc32)cn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 3/20 0.38
CDK6 Q00534 3/20 0.38
KDM4E B2RXH2 2/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KDM4A O75164 1/20 0.36
KDM5C P41229 1/20 0.36
KDM4D Q6B0I6 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
IDO1 P14902 1/20 0.35
MAOA P21397 4/20 0.35
MAOB P27338 4/20 0.35
ACHE P22303 1/20 0.35
KCNH2 Q12809 1/20 0.34
DYRK1A Q13627 2/20 0.33
CYP1A2 P05177 1/20 0.33
METAP2 P50579 1/20 0.33
NFATC1 O95644 1/20 0.33
GSK3B P49841 1/20 0.33
CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16640323 0.92 MAOA (0.43) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL16640324 0.90 ATM (0.46) KDM4EATML3MBTL1CYP1A2
SCHEMBL16644614 0.82 AOC3 (0.41) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL16640317 0.82 KDM4E (0.44) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL16640330 0.81 PDE4A (0.37) KDM4EATML3MBTL1KCNH2CYP1A2
SCHEMBL16640329 0.81 HTT (0.35) KDM4EATML3MBTL1IDO1CYP1A2
SCHEMBL23438634 0.79 KDM4E (0.52) KDM4EATML3MBTL1MAOAMAOB
SCHEMBL11978684 0.77 KDM4E (0.48) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL261830 0.76 KDM4E (0.52) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL5021391 0.76 KDM4E (0.50) CDK4CDK6KDM4EATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11189808-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2021-11-30 US disclosed
US-20200152891-A1 PLATINUM COMPLEXES AND DEVICES UNIV ARIZONA STATE (US) 2020-05-14 US disclosed
US-10566553-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-02-18 US disclosed
US-20190312210-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2019-10-10 US disclosed
US-9385329-B2 Platinum complexes and devices Arizona Board of Regents on behalf of Arizona State University and Universal Display Corporation (US) 2016-07-05 US disclosed
US-20150105556-A1 PLATINUM COMPLEXES AND DEVICES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2015-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11189808-B2 Platinum complexes and devices OXA1L, OCIAD1, OCIAD2 CDK4 2561/4885CDK6 2311/4885KDM4E 4835/4885
US-10566553-B2 Platinum complexes and devices OXA1L, OCIAD1, OCIAD2 CDK4 2561/4885CDK6 2311/4885KDM4E 4835/4885
US-20200152891-A1 PLATINUM COMPLEXES AND DEVICES OXA1L, OCIAD1, OCIAD2 CDK4 2561/4885CDK6 2311/4885KDM4E 4835/4885
US-20190312210-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SLCO4C1, SLCO2A1, SLCO1A2 CDK4 2028/4885CDK6 2708/4885KDM4E 3411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.