Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 6/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6126420 | 0.95 | NPC1 (0.45) | PDE7ALCKMAPK14MAPTALDH1A1 | |
| SCHEMBL1666529 | 0.85 | MAPT (0.41) | PDE7ALCKMAPK14MAPTALDH1A1 | |
| SCHEMBL6126449 | 0.85 | NPC1 (0.47) | PDE7ALCKMAPK14MAPTALDH1A1 | |
| SCHEMBL6126025 | 0.85 | NPC1 (0.47) | PDE7ALCKMAPK14MAPTALDH1A1 | |
| SCHEMBL1664832 | 0.82 | PDE7A (0.41) | PDE7ALCKMAPK14MAPTALDH1A1 | |
| SCHEMBL1663915 | 0.81 | PDE7A (0.42) | PDE7AMAPTALDH1A1MCL1KMT2A | |
| SCHEMBL1664802 | 0.81 | HPGDS (0.55) | PDE7AMAPTKMT2ANPC1RAB9A | |
| SCHEMBL1665848 | 0.81 | PDE7A (0.40) | PDE7AMAPTALDH1A1KMT2ANPC1 | |
| SCHEMBL1664362 | 0.81 | HPGDS (0.56) | PDE7AMAPTALDH1A1MCL1NPC1 | |
| SCHEMBL1666960 | 0.81 | ALDH1A1 (0.46) | PDE7AMAPK14MAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |