Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16633125 | 0.81 | NT5E (0.42) | LMNAHTTSMN1; SMN2CCNCCDK8 | |
| SCHEMBL16460893 | 0.76 | RORC (0.41) | LMNAHTTSMN1; SMN2L3MBTL1VKORC1 | |
| SCHEMBL16632633 | 0.71 | RORC (0.42) | — | |
| SCHEMBL16460911 | 0.70 | CYP1A2 (0.45) | LMNAHTTSMN1; SMN2L3MBTL1VKORC1 | |
| SCHEMBL12749514 | 0.70 | CYP1A2 (0.54) | LMNAHTTSMN1; SMN2CCNCCDK8 | |
| SCHEMBL16632923 | 0.69 | VKORC1 (0.42) | LMNASMN1; SMN2VKORC1KDM4EALDH1A1 | |
| SCHEMBL12749451 | 0.68 | AURKA (0.59) | PTGFRRXFP1CRHBPCRHR2MAPT | |
| SCHEMBL6379346 | 0.68 | BCL2 (0.40) | HTTKDM4EALDH1A1 | |
| SCHEMBL18102298 | 0.68 | DPP4 (0.51) | HTTSMN1; SMN2DPP4L3MBTL1KMT2A | |
| SCHEMBL16632999 | 0.68 | CYP1A2 (0.48) | LMNAHTTSMN1; SMN2CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150105366-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105366-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | LMNA 3340/4885HTT 2376/4885SMN1; SMN2 4233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.