Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 5/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | ICMT | O60725 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | HTR1B | P28222 | 4/20 | 0.49 |
| ▸ | HTR1D | P28221 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28551447 | 0.87 | ALDH1A1 (0.56) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 | |
| SCHEMBL1519943 | 0.84 | CYP2C19 (1.00) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 | |
| SCHEMBL138121 | 0.82 | NPSR1 (1.00) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 | |
| SCHEMBL29350604 | 0.82 | NPSR1 (1.00) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 | |
| SCHEMBL14487735 | 0.82 | HPGD (0.58) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 | |
| SCHEMBL5337098 | 0.81 | TSHR (0.66) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 | |
| SCHEMBL1615011 | 0.81 | TSHR (0.69) | HPGDTSHRCYP2C9ALDH1A1LMNA | |
| SCHEMBL6116786 | 0.81 | TSHR (0.69) | HPGDTSHRCYP2C9ALDH1A1LMNA | |
| SCHEMBL5067817 | 0.81 | TSHR (0.69) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 | |
| SCHEMBL31238472 | 0.81 | TSHR (0.69) | HPGDCYP2C19TSHRCYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |