Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | GPX4 | P36969 | 6/20 | 0.43 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664593 | 0.95 | HPGDS (0.45) | HPGDSIMPDH2GPX4EML4ALK | |
| SCHEMBL1664387 | 0.94 | KMT2A (0.47) | HPGDSIMPDH2HTR1DHTR1BMEN1 | |
| SCHEMBL1664596 | 0.88 | HPGDS (0.46) | HPGDSIMPDH2HTR1DHTR1BMEN1 | |
| SCHEMBL1664653 | 0.87 | HPGDS (0.51) | HPGDSEML4ALKGRM1KMT2A | |
| SCHEMBL1664464 | 0.86 | HPGDS (0.50) | HPGDSGRM1NPY2RMEN1KMT2A | |
| SCHEMBL1664452 | 0.84 | HPGDS (0.48) | HPGDSEML4ALKGRM1NPY2R | |
| SCHEMBL1664657 | 0.83 | HPGDS (0.51) | HPGDSHTR1DHTR1BGRM1MEN1 | |
| SCHEMBL1665157 | 0.82 | HPGDS (0.46) | HPGDSGRM1NPY2RMEN1KMT2A | |
| SCHEMBL1664466 | 0.82 | HPGDS (0.48) | HPGDSGRM1NPY2R | |
| SCHEMBL1664479 | 0.80 | CYP2C9 (0.45) | HPGDSEML4ALKNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |