Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.51 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | ROS1 | P08922 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664657 | 0.93 | HPGDS (0.51) | HPGDSPDE7AGRM1NPC1RAB9A | |
| SCHEMBL1664464 | 0.89 | HPGDS (0.50) | HPGDSPDE7AGRM1NPC1RAB9A | |
| SCHEMBL1663209 | 0.87 | HPGDS (0.51) | HPGDSPDE7AGRM1NPC1RAB9A | |
| SCHEMBL1664384 | 0.87 | HPGDS (0.48) | HPGDSGRM1EML4ALKKMT2A | |
| SCHEMBL1664868 | 0.86 | HPGDS (0.57) | HPGDSPDE7ANPC1RAB9AEGFR | |
| SCHEMBL1664452 | 0.86 | HPGDS (0.48) | HPGDSGRM1EML4ALKRET | |
| SCHEMBL1665157 | 0.85 | HPGDS (0.46) | HPGDSPDE7AGRM1NPC1RAB9A | |
| SCHEMBL1664466 | 0.84 | HPGDS (0.48) | HPGDSPDE7AGRM1NPC1RAB9A | |
| SCHEMBL1663740 | 0.84 | HPGDS (0.56) | HPGDSPDE7AGRM1NPC1RAB9A | |
| SCHEMBL1663743 | 0.83 | HPGDS (0.54) | HPGDSNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |