Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 3/20 | 0.41 |
| ▸ | MTTP | P55157 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | SIK1 | P57059 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665157 | 0.95 | HPGDS (0.46) | HPGDSPDE7ANPC1RAB9AMAPT | |
| SCHEMBL1664466 | 0.93 | HPGDS (0.48) | HPGDSPDE7ANPC1RAB9AMAPT | |
| SCHEMBL1664653 | 0.89 | HPGDS (0.51) | HPGDSPDE7ANPC1RAB9AGRM1 | |
| SCHEMBL1664362 | 0.89 | HPGDS (0.56) | HPGDSPDE7ANPC1RAB9AMAPT | |
| SCHEMBL1664452 | 0.87 | HPGDS (0.48) | HPGDSMAPTSMN1; SMN2GRM1NPY2R | |
| SCHEMBL1665159 | 0.87 | HPGDS (0.48) | HPGDSPDE7ANPC1RAB9AMAPT | |
| SCHEMBL1664384 | 0.86 | HPGDS (0.48) | HPGDSGRM1KMT2AMEN1NPY2R | |
| SCHEMBL1664802 | 0.85 | HPGDS (0.55) | HPGDSPDE7ANPC1RAB9AMAPT | |
| SCHEMBL6125839 | 0.85 | HPGDS (0.50) | HPGDSPDE7ANPC1RAB9AMAPT | |
| SCHEMBL1664657 | 0.84 | HPGDS (0.51) | HPGDSPDE7ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |