Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186951 | 0.91 | ALOX15 (0.43) | KDM4EALDH1A1HSD17B10CA1CA2 | |
| SCHEMBL4752382 | 0.84 | ALDH1A1 (0.39) | KDM4EALDH1A1HSD17B10CA1CA2 | |
| SCHEMBL647371 | 0.77 | KDM4E (0.67) | KDM4EGLAALDH1A1CFTRHSD17B10 | |
| SCHEMBL27597208 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1CFTRHSD17B10KMT2A | |
| SCHEMBL4751298 | 0.73 | ALDH1A1 (0.60) | KDM4EGLAALDH1A1HSD17B10KMT2A | |
| SCHEMBL14575778 | 0.73 | TSHR (0.56) | KDM4EALDH1A1CFTRHSD17B10KMT2A | |
| SCHEMBL31634613 | 0.71 | ALDH1A1 (0.58) | KDM4EGLAALDH1A1CFTRHSD17B10 | |
| SCHEMBL465737 | 0.71 | ALDH1A1 (0.58) | KDM4EGLAALDH1A1CFTRHSD17B10 | |
| SCHEMBL8591498 | 0.70 | ALOX15 (0.50) | KDM4EALDH1A1CFTRHSD17B10KMT2A | |
| SCHEMBL28476762 | 0.70 | MAPT (0.55) | KDM4EALDH1A1HSD17B10CA9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |