SCHEMBL16645137

CCC(=O)OCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)[C@@H](OC)[C@@H]1CCCN1C(=O)C[C@@H](C)[C@@H](NOC)[C@@H](C)CC

nearest known ligand 0.41

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	2/20	0.41

▸	ACE	P12821	7/20	0.39

▸	ACE2	Q9BYF1	5/20	0.39

▸	TSHR	P16473	1/20	0.35

▸	ATM	Q13315	1/20	0.35

▸	L3MBTL1	Q9Y468	1/20	0.35

▸	PTPN1	P18031	1/20	0.34

▸	TACR2	P21452	2/20	0.34

▸	CHRNA1	P02708	1/20	0.34

▸	CHRNG	P07510	1/20	0.34

▸	CHRNB1	P11230	1/20	0.34

▸	CHRND	Q07001	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16645117	0.90	REN (0.40)	RENACEACE2TSHRATM
SCHEMBL16645207	0.90	REN (0.40)	RENACEACE2TSHRATM
SCHEMBL16645035	0.88	REN (0.42)	RENACEACE2TSHRATM
SCHEMBL26536406	0.87	REN (0.40)	RENACEACE2TSHRATM
SCHEMBL16645063	0.83	REN (0.41)	RENACEACE2TSHRATM
SCHEMBL16645069	0.83	REN (0.40)	RENACEACE2TSHRATM
SCHEMBL17384263	0.83	REN (0.40)	RENACEACE2TSHRATM
SCHEMBL16645016	0.82	REN (0.42)	RENACEACE2TSHRATM
SCHEMBL19443260	0.82	CYP3A4 (0.38)	RENACEACE2TACR2
SCHEMBL17381819	0.82	REN (0.40)	RENACEACE2CHRNA1CHRNG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2015054669-A1	PROTEIN-POLYMER-DRUG CONJUGATES	ASANA BIOSCIENCES, LLC (US)	2015-04-16	—	—	WO	disclosed