⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL224066 | 0.81 | PRKCA (0.33) | — | |
| SCHEMBL27055120 | 0.81 | PRKCA (0.33) | — | |
| SCHEMBL14349630 | 0.81 | PRKCA (0.33) | — | |
| SCHEMBL10084376 | 0.81 | — | — | |
| SCHEMBL12295830 | 0.81 | — | — | |
| SCHEMBL2754578 | 0.77 | TSHR (0.31) | — | |
| SCHEMBL2754589 | 0.77 | TSHR (0.31) | — | |
| SCHEMBL15811681 | 0.76 | — | — | |
| SCHEMBL22016350 | 0.76 | THRB (0.32) | — | |
| SCHEMBL325804 | 0.75 | TSHR (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9849191-B2 | Protein-polymer-drug conjugates | MERSANA THERAPEUTICS, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20150125474-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. | 2015-05-07 | — | — | US | disclosed |
| US-20150104407-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. | 2015-04-16 | — | — | US | disclosed |