Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 20/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29581491 | 1.00 | MAPT (0.63) | MAPT | |
| Acetic Acid SCHEMBL21407452 | 0.94 | MAPT (0.61) | MAPT | |
| SCHEMBL17967652 | 0.83 | MAPT (0.68) | MAPT | |
| SCHEMBL29598856 | 0.81 | MAPT (0.81) | MAPT | |
| SCHEMBL16634186 | 0.81 | MAPT (0.81) | MAPT | |
| SCHEMBL17975131 | 0.81 | MAPT (0.81) | MAPT | |
| SCHEMBL13465254 | 0.81 | MAPT (0.56) | MAPT | |
| SCHEMBL19958142 | 0.80 | MAPT (0.71) | MAPT | |
| SCHEMBL27097292 | 0.80 | MAPT (0.67) | MAPT | |
| SCHEMBL19958143 | 0.78 | MAPT (0.65) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11058781-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. | 2021-07-13 | — | — | US | disclosed |
| EP-3510031-B1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | HOFFMANN LA ROCHE (CH) | 2020-12-02 | — | — | EP | disclosed |
| EP-3510031-B1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | HOFFMANN LA ROCHE (CH) | 2020-12-02 | — | — | EP | disclosed |
| US-20190300529-A1 | Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole | HOFFMANN-LA ROCHE INC. (US) | 2019-10-03 | — | — | US | disclosed |
| US-10004817-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-10004817-B2 | Diazacarbazole derivatives as tau-PET-ligands | HOFFMANN-LA ROCHE INC. (US) | 2018-06-26 | — | — | US | disclosed |
| WO-2018046428-A1 | PROCESS FOR PREPARATION OF 2-(6-NITROPYRIDIN-3-YL)-9H-DIPYRIDO[2,3-B;3',4'-D]PYRROLE | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-15 | — | — | WO | disclosed |
| EP-3055308-B1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN LA ROCHE (CH) | 2017-11-22 | — | — | EP | disclosed |
| US-20160220712-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN-LA ROCHE INC. (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160220712-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | HOFFMANN-LA ROCHE INC. (US) | 2016-08-04 | — | — | US | disclosed |
| WO-2015052105-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10004817-B2 | Diazacarbazole derivatives as tau-PET-ligands | SNCA, MAPT, PSEN1 | MAPT 2/4885 |
| US-11058781-B2 | Diazacarbazole derivatives as tau-PET-ligands | SNCA, MAPT, PSEN1 | MAPT 2/4885 |
| US-20160220712-A1 | DIAZACARBAZOLE DERIVATIVES AS TAU-PET-LIGANDS | SNCA, MAPT, PSEN1 | MAPT 2/4885 |
| US-20190300529-A1 | Process for preparation of 2-(6-nitropyridin-3-yl)-9H-dipyrido[2,3-b;3',4'-d]pyrrole | HBB, PAH, BOLA2; BOLA2B | MAPT 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.