Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 2/20 | 0.53 |
| ▸ | ADH5 | P11766 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 2/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646011 | 0.82 | ALDH1A1 (0.58) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL4443620 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL15059787 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL22273714 | 0.81 | ALOX5 (0.63) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL2963261 | 0.81 | ALDH1A1 (0.61) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL18603158 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL2646013 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL750501 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBADH5ALOX5XDH | |
| SCHEMBL3743779 | 0.80 | ALDH1A1 (0.56) | ALDH1A1RARBADH5ALOX5XDH | |
| Hydrochloric Acid SCHEMBL12803102 | 0.79 | ALDH1A1 (0.55) | ALDH1A1RARBADH5ALOX5XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-B1 | KHK INHIBITORS | GILEAD SCIENCES INC (US) | 2025-11-12 | — | — | EP | disclosed |
| US-12410160-B2 | KHK inhibitors | GILEAD SCIENCES, INC. (US) | 2025-09-09 | — | — | US | disclosed |
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| US-20230079863-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. | 2023-03-16 | — | — | US | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230079863-A1 | KHK INHIBITORS | KHK, KHDRBS1, NADK | ALDH1A1 1520/4885RARB 3604/4885ADH5 972/4885 |
| US-12410160-B2 | KHK inhibitors | KHK, KHDRBS1, NADK | ALDH1A1 1520/4885RARB 3604/4885ADH5 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.