Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 2/20 | 0.53 |
| ▸ | XDH | P47989 | 2/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.52 |
| ▸ | ADH5 | P11766 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750501 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| SCHEMBL16645310 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| SCHEMBL15059787 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| SCHEMBL22273714 | 0.81 | ALOX5 (0.63) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| SCHEMBL18603158 | 0.81 | ALDH1A1 (0.57) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| SCHEMBL4909745 | 0.80 | ALDH1A1 (0.53) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| SCHEMBL3743779 | 0.80 | ALDH1A1 (0.56) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| Hydrochloric Acid SCHEMBL12803102 | 0.79 | ALDH1A1 (0.55) | ALDH1A1RARBXDHSLC22A12ADH5 | |
| SCHEMBL2645921 | 0.79 | PARP1 (0.45) | ALDH1A1RARBXDHSLC22A12PARP1 | |
| SCHEMBL750500 | 0.79 | PARP1 (0.58) | ALDH1A1RARBXDHSLC22A12ADH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| US-7728025-B2 | 2-heteroaryl-substituted benzimidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-06-01 | — | — | US | disclosed |
| US-20080070928-A1 | Novel 2-Heteroaryl-Substituted Benzimidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070928-A1 | Novel 2-Heteroaryl-Substituted Benzimidazole Derivative | GCK, GCKR, HK1 | ALDH1A1 1188/4885RARB 2755/4885XDH 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.