Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 9/20 | 0.44 |
| ▸ | RAB9A | P51151 | 9/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663581 | 0.95 | RAB9A (0.48) | KDM4EHPGDNPC1RAB9APKM | |
| SCHEMBL1664550 | 0.95 | RAB9A (0.48) | KDM4EHPGDNPC1RAB9APKM | |
| SCHEMBL1665070 | 0.83 | NPC1 (0.45) | HPGDNPC1RAB9APKMHPGDS | |
| SCHEMBL1664289 | 0.82 | NPC1 (0.47) | KDM4ENPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL1668213 | 0.82 | MAPT (0.62) | KDM4EHPGDNPC1RAB9APKM | |
| SCHEMBL1665073 | 0.82 | NPC1 (0.46) | KDM4EHPGDNPC1RAB9APKM | |
| SCHEMBL1663623 | 0.81 | RAB9A (0.46) | KDM4ENPC1RAB9APKMHPGDS | |
| SCHEMBL1664351 | 0.80 | HPGDS (0.62) | KDM4ENPC1RAB9AHPGDSSMN1; SMN2 | |
| SCHEMBL1664469 | 0.80 | RAB9A (0.58) | KDM4EHPGDNPC1RAB9APKM | |
| SCHEMBL8769706 | 0.80 | RAB9A (0.58) | KDM4EHPGDNPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |