Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 5/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.43 |
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665073 | 0.94 | NPC1 (0.46) | NPC1RAB9APKMBACE1BACE2 | |
| SCHEMBL6126046 | 0.85 | GPR6 (0.45) | NPC1RAB9APKMBACE1BACE2 | |
| SCHEMBL1663581 | 0.84 | RAB9A (0.48) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL1664549 | 0.83 | KDM4E (0.45) | NPC1RAB9APKMPDE7ASMN1; SMN2 | |
| SCHEMBL6126242 | 0.82 | NPC1 (0.45) | NPC1RAB9APKMPDE7ASMN1; SMN2 | |
| SCHEMBL6126449 | 0.81 | NPC1 (0.47) | NPC1RAB9APDE7ASMN1; SMN2TP53 | |
| SCHEMBL6126048 | 0.81 | NPC1 (0.43) | NPC1RAB9APKMBACE1BACE2 | |
| SCHEMBL1666960 | 0.81 | ALDH1A1 (0.46) | NPC1RAB9APDE7ASMN1; SMN2CSF1R | |
| SCHEMBL6120725 | 0.80 | RAB9A (0.51) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL1664802 | 0.80 | HPGDS (0.55) | NPC1RAB9APDE7ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |