Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.61 |
| ▸ | NPC1 | O15118 | 12/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HPGDS | O60760 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664782 | 0.95 | NPC1 (0.66) | RAB9ANPC1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL1665100 | 0.84 | HPGDS (0.54) | RAB9ANPC1SMN1; SMN2HPGDSKMT2A | |
| SCHEMBL1663295 | 0.83 | HPGDS (0.63) | RAB9ANPC1SMN1; SMN2HPGDSKMT2A | |
| SCHEMBL1665278 | 0.83 | HPGDS (0.45) | RAB9ANPC1SMN1; SMN2TSHRHPGDS | |
| SCHEMBL1666278 | 0.82 | HPGDS (0.60) | RAB9ANPC1HPGDS | |
| SCHEMBL1664351 | 0.82 | HPGDS (0.62) | RAB9ANPC1SMN1; SMN2HPGDSKMT2A | |
| SCHEMBL1664885 | 0.82 | HPGDS (0.47) | RAB9ANPC1SMN1; SMN2TSHRHPGDS | |
| SCHEMBL1664840 | 0.81 | HPGDS (0.61) | RAB9ANPC1HPGDSKMT2AMEN1 | |
| SCHEMBL1664300 | 0.81 | MAPT (0.44) | RAB9ANPC1TSHRHPGDSKMT2A | |
| SCHEMBL1664361 | 0.81 | HPGDS (0.58) | RAB9ANPC1HPGDSKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |