Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30962894 | 0.88 | CHRNA7 (0.48) | PIN1CHRNA7MAPTMEN1KMT2A | |
| SCHEMBL30962730 | 0.88 | POLB (0.46) | CHRNA7MAPTMEN1KMT2AKEAP1 | |
| SCHEMBL30962582 | 0.81 | CHRNA7 (0.41) | CHRNA7MAPTMEN1KMT2AKEAP1 | |
| SCHEMBL30962627 | 0.80 | PDE4A (0.43) | CHRNA7MAPTMEN1KMT2AKEAP1 | |
| SCHEMBL30962815 | 0.79 | CHRNA7 (0.40) | PIN1CHRNA7MAPTMEN1KMT2A | |
| SCHEMBL30962881 | 0.79 | NFKB1 (0.48) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL30962741 | 0.77 | PDE4A (0.43) | MAPTPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL4499760 | 0.77 | MAP3K7 (0.60) | LCK | |
| SCHEMBL30962863 | 0.76 | NFKB1 (0.42) | PIN1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2946609 | 0.76 | NFKB1 (0.52) | CHRNA7MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526096-B1 | 4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-04-22 | — | — | EP | claimed |
| EP-2526096-B1 | 4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-04-22 | — | — | EP | disclosed |