Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.45 |
| ▸ | KIF11 | P52732 | 7/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020708 | 0.82 | KIF11 (0.42) | KIF11FFAR1KDM1APDE2ASLC6A4 | |
| SCHEMBL15157706 | 0.82 | KIF11 (0.42) | KIF11FFAR1KDM1APDE2ASLC6A4 | |
| SCHEMBL15157447 | 0.82 | KIF11 (0.42) | KIF11FFAR1KDM1APDE2ASLC6A4 | |
| SCHEMBL28196899 | 0.81 | ADRA2A (0.60) | AKT1ADRB1ADRA2AADRB3ADRA2B | |
| SCHEMBL28196898 | 0.81 | ADRA2A (0.60) | AKT1ADRB1ADRA2AADRB3ADRA2B | |
| SCHEMBL14980670 | 0.80 | KIF11 (0.43) | KIF11FFAR1KDM1APDE2ASLC7A5 | |
| SCHEMBL16649703 | 0.80 | SLC7A5 (0.45) | KIF11FFAR1KDM1APDE2ASLC7A5 | |
| SCHEMBL14980644 | 0.79 | KIF11 (0.42) | KIF11FFAR1KDM1APDE2ASLC7A5 | |
| SCHEMBL12498078 | 0.78 | PDE2A (0.39) | KIF11FFAR1KDM1APDE2ASLC7A5 | |
| SCHEMBL16649911 | 0.78 | PDE2A (0.39) | KIF11FFAR1KDM1APDE2ASLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |