Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 2/20 | 0.53 |
| ▸ | NOS1 | P29475 | 5/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.43 |
| ▸ | HTR3B | O95264 | 3/20 | 0.43 |
| ▸ | HTR3A | P46098 | 3/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.43 |
| ▸ | HGFAC | Q04756 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL5034246 | 0.88 | HTR3E (0.48) | TSHRPLAUNOS1HTR3EHTR3B | |
| Nitric Acid SCHEMBL13739226 | 0.81 | HTR3E (0.42) | TSHRPLAUNOS1HTR3EHTR3B | |
| Nitric Acid SCHEMBL27330996 | 0.78 | PLAU (0.50) | PLAUNOS1HTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL1674 | 0.77 | PLAU (0.49) | TSHRPLAUNOS1HTR3EHTR3B | |
| SCHEMBL14513560 | 0.75 | TSHR (0.65) | TSHRCYP3A4SMN1; SMN2ACHEGPR35 | |
| Nitric Acid SCHEMBL1368 | 0.75 | HTR3E (0.72) | TSHRPLAUHTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL7813484 | 0.75 | HTR3E (0.77) | TSHRPLAUNOS1HTR3EHTR3B | |
| SCHEMBL27886596 | 0.74 | HTR3E (0.61) | TSHRPLAUHTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL3860515 | 0.74 | PLAU (0.92) | TSHRPLAUNOS1HGFACNOS3 | |
| SCHEMBL11878118 | 0.73 | PLAU (0.50) | TSHRPLAUNOS1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1043531-C | Pyrimidine derivatives and a process for production thereof | NOVATIS AG (CH) | 1999-06-02 | — | — | CN | disclosed |
| US-5521184-A | ANTITUMOR AGENTS; imatinib mesylate | CIBA-GEIGY CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| CN-1077713-A | Pyrimidine derivatives and preparation method thereof | CIBA GEIGY AG (CH) | 1993-10-27 | — | — | CN | disclosed |