Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.46 |
| ▸ | HTR3B | O95264 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.38 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HGFAC | Q04756 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL5733225 | 0.78 | HTR3E (0.79) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL1665 | 0.77 | TSHR (0.53) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11884390 | 0.77 | ITGB3 (0.71) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Hydrazine SCHEMBL28307217 | 0.75 | TSHR (0.52) | PTPN5ALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL1005841 | 0.75 | TSHR (0.55) | PTPN5ALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL1996062 | 0.75 | ALDH1A1 (0.55) | PTPN5ALDH1A1CYP3A4HPGDALOX15 | |
| Nitric Acid SCHEMBL27330996 | 0.75 | PLAU (0.50) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1946009 | 0.74 | ALDH1A1 (0.41) | PTPN5ALDH1A1CYP3A4HPGDALOX15 | |
| Hydrochloric Acid SCHEMBL28212666 | 0.73 | TSHR (0.53) | PTPN5ALDH1A1CYP3A4HPGDALOX15 | |
| Nitric Acid SCHEMBL1368 | 0.72 | HTR3E (0.72) | PLAUHTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521184-A | ANTITUMOR AGENTS; imatinib mesylate | CIBA-GEIGY CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |