SCHEMBL1665235

SCHEMBL1665235

NCc1cn([C@@H]2O[C@H](CO)C(O)C2O)c(=O)nc1N

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.60
MTOR P42345 2/20 0.60
ALDH1A1 P00352 2/20 0.60
TP53 P04637 2/20 0.60
DNMT1 P26358 2/20 0.60
THRB P10828 1/20 0.60
MDM2 Q00987 1/20 0.60
NCOA1 Q15788 1/20 0.60
NCOA3 Q9Y6Q9 1/20 0.60
GMNN O75496 1/20 0.60
NFKB1 P19838 1/20 0.60
THPO P40225 1/20 0.60
HTT P42858 1/20 0.60
RAB9A P51151 1/20 0.60
BLM P54132 1/20 0.60
HBB P68871 1/20 0.60
PMP22 Q01453 1/20 0.60
SMN1; SMN2 Q16637 2/20 0.51
MAPT P10636 2/20 0.51
CDA P32320 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15445177 1.00 LMNA (0.60) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL1665233 1.00 LMNA (0.60) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL16805407 0.91 LMNA (0.62) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL156037 0.91 LMNA (0.62) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL18858919 0.91 LMNA (0.62) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL9856439 0.91 LMNA (0.62) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL9856409 0.91 LMNA (0.62) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL156036 0.91 LMNA (0.62) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL6829082 0.90 LMNA (0.58) LMNAMTORALDH1A1TP53DNMT1
SCHEMBL6418055 0.90 LMNA (0.60) LMNAMTORALDH1A1TP53DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11518779-B2 Inhibitors of DNMT1 as anticancer therapeutic agents VICTORIA LINK LIMITED (NZ) 2022-12-06 US disclosed
EP-3670523-B1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND THEIR USE IN METHODS FOR NUCLEIC ACID SEQUENCING AGILENT TECHNOLOGIES INC (US) 2021-08-11 EP disclosed
US-20210206795-A1 INHIBITORS OF DNMT1 AS ANTICANCER THERAPEUTIC AGENTS VICTORIA LINK LTD (NZ) 2021-07-08 US disclosed
US-11001886-B2 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing AGILENT TECHNOLOGIES, INC. (US) 2021-05-11 US disclosed
EP-3670523-A1 5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING Agilent Technologies, Inc. (US) 2020-06-24 EP disclosed
EP-2755984-B1 5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING AGILENT TECHNOLOGIES INC (US) 2020-02-12 EP disclosed
US-20190127790-A1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING AGILENT TECHNOLOGIES, INC. 2019-05-02 US disclosed
US-10041115-B2 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing LASERGEN, INC. (US) 2018-08-07 US disclosed
EP-2307565-B1 REVERSIBLE NUCLEOSIDES AND NUCLEOTIDES TERMINATORS AND THEIR USE IN DNA SEQUENCING LASERGEN INC (US) 2017-11-29 EP disclosed
US-20170327886-A1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING LASERGEN, INC. (US) 2017-11-16 US disclosed
EP-2755984-A1 5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING Lasergen, Inc. (US) 2014-07-23 EP disclosed
US-20140051848-A1 NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING AGILENT TECHNOLOGIES, INC. 2014-02-20 US disclosed
US-8497360-B2 Nucleotides and nucleosides and methods for their use in DNA sequencing LASERGEN, INC. (US) 2013-07-30 US disclosed
US-20130122489-A1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING AGILENT TECHNOLOGIES, INC. 2013-05-16 US disclosed
WO-2013040257-A1 5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING LASERGEN, INC. (US) 2013-03-21 WO disclosed
US-20130035237-A1 Nucleotides and Nucleosides and Methods for their Use in DNA Sequencing AGILENT TECHNOLOGIES, INC. 2013-02-07 US disclosed
US-8148503-B2 Nucleotides and nucleosides and methods for their use in DNA sequencing LASERGEN, INC. (US) 2012-04-03 US disclosed
EP-2307565-A2 NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING Lasergen, Inc. (US) 2011-04-13 EP disclosed
US-20100041041-A1 NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING AGILENT TECHNOLOGIES, INC. 2010-02-18 US disclosed
WO-2009152353-A2 NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING LASERGEN, INC. (US) 2009-12-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11518779-B2 Inhibitors of DNMT1 as anticancer therapeutic agents DNMT1, DNMT3A, DNMT3B LMNA 2673/4885MTOR 840/4885ALDH1A1 669/4885
US-20100041041-A1 NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING UNG, NT5C2, NT5E LMNA 357/4885MTOR 4784/4885ALDH1A1 1889/4885
US-20190127790-A1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING RNGTT, NT5C3B, NSUN2 LMNA 275/4885MTOR 4849/4885ALDH1A1 2244/4885
US-20210206795-A1 INHIBITORS OF DNMT1 AS ANTICANCER THERAPEUTIC AGENTS DNMT1, DNMT3B, DNMT3A LMNA 2458/4885MTOR 601/4885ALDH1A1 466/4885
US-10041115-B2 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing RNGTT, NT5C3B, NSUN2 LMNA 275/4885MTOR 4845/4885ALDH1A1 2163/4885
US-11001886-B2 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing RNGTT, NT5C3B, NSUN2 LMNA 275/4885MTOR 4845/4885ALDH1A1 2163/4885
US-20170327886-A1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING RNGTT, NT5C3B, NSUN2 LMNA 275/4885MTOR 4849/4885ALDH1A1 2244/4885
US-20130035237-A1 Nucleotides and Nucleosides and Methods for their Use in DNA Sequencing UNG, NT5C2, NT5E LMNA 357/4885MTOR 4784/4885ALDH1A1 1889/4885
US-20130122489-A1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING RNGTT, NT5C3B, NSUN2 LMNA 275/4885MTOR 4849/4885ALDH1A1 2244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.