Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 9/20 | 0.53 |
| ▸ | RAMP1 | O60894 | 8/20 | 0.53 |
| ▸ | CCKBR | P32239 | 11/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3699627 | 1.00 | CALCRL (0.53) | CALCRLRAMP1CCKBR | |
| SCHEMBL35210147 | 0.89 | CALCRL (0.50) | CALCRLRAMP1CCKBR | |
| SCHEMBL20664220 | 0.89 | CALCRL (0.50) | CALCRLRAMP1CCKBR | |
| SCHEMBL15280637 | 0.89 | CALCRL (0.50) | CALCRLRAMP1CCKBR | |
| SCHEMBL30683670 | 0.88 | CALCRL (0.51) | CALCRLRAMP1CCKBR | |
| SCHEMBL16653184 | 0.88 | CALCRL (0.51) | CALCRLRAMP1CCKBR | |
| SCHEMBL16661435 | 0.83 | CALCRL (0.44) | CALCRLRAMP1 | |
| SCHEMBL21919542 | 0.81 | RAMP1 (0.42) | CALCRLRAMP1 | |
| SCHEMBL16661421 | 0.81 | RAMP1 (0.42) | CALCRLRAMP1 | |
| SCHEMBL3694821 | 0.81 | RAMP1 (0.42) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10106541-B2 | Intermediates for preparing CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-10-23 | — | — | US | disclosed |
| US-20180127417-A1 | INTERMEDIATES FOR PREPARING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-05-10 | — | — | US | disclosed |
| US-9487523-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-08 | — | — | US | disclosed |
| US-9174989-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20150112067-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10106541-B2 | Intermediates for preparing CGRP receptor antagonists | CALCR, CALCRL, VIPR1 | CALCRL 2/4885RAMP1 11/4885CCKBR 15/4885 |
| US-20180127417-A1 | INTERMEDIATES FOR PREPARING CGRP RECEPTOR ANTAGONISTS | CALCR, CALCRL, VIPR1 | CALCRL 2/4885RAMP1 11/4885CCKBR 15/4885 |
| US-20150112067-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | CCKBR, BDKRB2, CALCR | CALCRL 7/4885RAMP1 19/4885CCKBR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.