Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | TYMP | P19971 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22423310 | 0.79 | CYP2A6 (0.53) | ALDH1A1GSK3BDYRK1ATYMPBTK | |
| SCHEMBL3485414 | 0.78 | ALDH1A1 (1.00) | ALDH1A1TYMPLMNAHPGDKDM4E | |
| SCHEMBL13314184 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPK1LMNATDO2 | |
| SCHEMBL6535585 | 0.74 | AURKA (0.54) | GSK3BDYRK1AMAPK1AURKATTK | |
| Hydrochloric Acid SCHEMBL3561023 | 0.74 | ALDH1A1 (0.51) | ALDH1A1MAPK1LMNATDO2 | |
| SCHEMBL21563927 | 0.73 | DYRK1A (0.51) | ALDH1A1GSK3BDYRK1ATYMPMAPK1 | |
| SCHEMBL15850324 | 0.73 | GSK3B (0.48) | ALDH1A1GSK3BTYMPBTKCYP1A2 | |
| SCHEMBL31235677 | 0.72 | NUDT1 (0.49) | ALDH1A1GSK3BDYRK1ATYMPMAPK1 | |
| SCHEMBL2101504 | 0.72 | NUDT1 (0.49) | ALDH1A1GSK3BDYRK1ATYMPMAPK1 | |
| SCHEMBL13314218 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MAPK1LMNACYP2A6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875006-B1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2018-12-26 | — | — | EP | disclosed |
| US-9428465-B2 | Acid ceramidase inhibitors and their use as medicaments | FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA (IT) | 2016-08-30 | — | — | US | disclosed |
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | ASAH1, ASAH2, ACER2 | ALDH1A1 641/4885GSK3B 868/4885DYRK1A 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.