Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665339 | 0.96 | HPGDS (0.48) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8772007 | 0.90 | HPGDS (0.48) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1664854 | 0.82 | HPGDS (0.50) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1664185 | 0.81 | KMT2A (0.44) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1665847 | 0.80 | HPGDS (0.53) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1664088 | 0.80 | HPGDS (0.53) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1663295 | 0.80 | HPGDS (0.63) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1664351 | 0.79 | HPGDS (0.62) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1664860 | 0.79 | HPGDS (0.47) | HPGDSNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1664840 | 0.78 | HPGDS (0.61) | HPGDSNPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |