Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL631738 | 0.70 | S100A4 (0.33) | — | |
| SCHEMBL17106896 | 0.64 | KMT2A (0.39) | ALDH1A1HPGDPPARGSMN1; SMN2NPSR1 | |
| SCHEMBL7034667 | 0.59 | POLB (0.41) | POLBALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL10446539 | 0.58 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL6777717 | 0.58 | POLB (0.59) | POLBGAASMN1; SMN2 | |
| SCHEMBL8631968 | 0.58 | POLB (0.42) | POLBALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL1116173 | 0.57 | HSD17B10 (0.49) | POLBKDM4EALDH1A1LMNAGAA | |
| SCHEMBL38090 | 0.57 | POLB (0.41) | POLBALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL6504974 | 0.57 | POLB (0.61) | POLBALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL16671336 | 0.56 | POLB (0.36) | POLBALDH1A1PPARGSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057421-A1 | ALKYL LINKED QUINOLINYL MODULATORS OF ROR(GAMMA)T | Janssen Pharmaceutica, N.V. (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057629-A1 | ALKYL LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |