Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131658 | 0.77 | — | — | |
| SCHEMBL38090 | 0.74 | POLB (0.41) | POLBGSTP1GSTM2HSD17B10EGFR | |
| SCHEMBL3287916 | 0.70 | TOP2A (0.41) | HSD17B10RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL10706324 | 0.70 | NPC1 (0.39) | POLBHSD17B10RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9034353 | 0.69 | POLB (0.42) | POLBHSD17B10EGFRRAB9ASMN1; SMN2 | |
| SCHEMBL6051921 | 0.69 | ALDH1A1 (0.41) | HSD17B10RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL6777717 | 0.67 | POLB (0.59) | POLBHSD17B10EGFRRAB9ASMN1; SMN2 | |
| SCHEMBL10763514 | 0.66 | POLB (0.45) | POLBHSD17B10EGFRRAB9ASMN1; SMN2 | |
| SCHEMBL558171 | 0.65 | KDM4E (0.41) | POLBHSD17B10RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4355515 | 0.65 | POLB (0.44) | POLBGSTP1GSTM2HSD17B10EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777406-B2 | SUCH AS PYRIDO(3,2,1-IJ)PYRROLO(3,4-C)QUINOLIN-8-ONE DERI-VATIVES; CENTRAL NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-17 | — | — | US | disclosed |